David Butler Selected Research

Dementia (Dementias)

1/2019	The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer's Disease and Parkinson's Disease and Models of Mild Cognitive Impairment.
4/2012	Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases.
5/2007	Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers.

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David Butler Research Topics

Disease

4	Infections 01/2022 - 08/2002
4	Alzheimer Disease (Alzheimer's Disease) 10/2017 - 01/2006
3	Dementia (Dementias) 01/2019 - 05/2007
3	Neoplasms (Cancer) 09/2003 - 08/2002
2	Zika Virus Infection 12/2020 - 10/2020
2	Traumatic Brain Injuries (Traumatic Brain Injury) 10/2017 - 04/2010
2	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2006 - 01/2005
2	Metaplasia 06/2004 - 09/2003
2	Carcinoma (Carcinomatosis) 09/2003 - 08/2002
1	Critical Illness (Critically Ill) 01/2022
1	Viremia 12/2020
1	Flavivirus Infections 12/2020
1	Healthcare-Associated Pneumonia 03/2019
1	Communicable Diseases (Infectious Diseases) 03/2019
1	Pneumonia (Pneumonitis) 03/2019
1	Ventilator-Associated Pneumonia 03/2019
1	Amyloid Plaque 01/2019
1	Synucleinopathies 01/2018
1	Parkinson Disease (Parkinson's Disease) 01/2018
1	Weight Gain 09/2016
1	Drug Resistant Epilepsy 09/2016
1	Stroke (Strokes) 04/2010
1	Hypercholesterolemia 08/2008
1	Cognitive Dysfunction 05/2007
1	Atrophy 07/2006
1	Cocaine-Related Disorders (Cocaine Addiction) 02/2006
1	Acquired Immunodeficiency Syndrome (AIDS) 06/2004
1	Barrett Esophagus (Barrett's Esophagus) 06/2004
1	Stomach Neoplasms (Stomach Cancer) 09/2003
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 09/2003
1	Adenocarcinoma 09/2003
1	Carcinogenesis 09/2003
1	Uterine Cervical Dysplasia 08/2002

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2019 - 08/2002
2	Pharmaceutical PreparationsIBA 03/2019 - 10/2017
1	CefiderocolIBA 01/2022
1	SiderophoresIBA 01/2022
1	Cephalosporins (Cephalosporin Antibiotics)IBA 01/2022
1	Antiviral Agents (Antivirals)IBA 12/2020
1	Methylene Blue (Methylthioninium Chloride)FDA Link 12/2020
1	Peptide Hydrolases (Proteases)FDA Link 12/2020
1	Niclosamide FDA Link 10/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2019
1	Polymyxins (Polymyxin)IBA 03/2019
1	Lysosomal Membrane ProteinsIBA 01/2019
1	SynucleinsIBA 01/2018
1	Single-Domain AntibodiesIBA 01/2018
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2018
1	Cysteine Proteinase InhibitorsIBA 10/2017
1	CalpainIBA 10/2017
1	Cathepsin BIBA 10/2017
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 09/2016
1	Peptides (Polypeptides)IBA 01/2011
1	Amyloid (Amyloid Fibrils)IBA 01/2011
1	fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA 04/2010
1	TubulinIBA 05/2007
1	Neurotransmitter Agents (Neurotransmitter)IBA 02/2006
1	Keratin-7 (Cytokeratin 7)IBA 06/2004
1	Mucin-1 (CA 15-3 Antigen)IBA 06/2004
1	AntralIBA 06/2004
1	Keratins (Keratin)IBA 06/2004
1	beta CateninIBA 09/2003
1	Cadherins (E-Cadherin)IBA 09/2003
1	fragile histidine triad proteinIBA 08/2002
1	micaIBA 08/2002

Therapy/Procedure

5	Therapeutics 12/2020 - 10/2017
1	Continuous Renal Replacement Therapy 01/2022
1	Ketogenic Diet 09/2016
1	RNAi Therapeutics 08/2008
1	Gastrectomy 09/2003